Severe neurologic manifestations in acute intermittent porphyria developed after spine surgery under general anesthesia: a case report

Porphyrias are inherited metabolic disorders resulting from a specific enzyme defect in the heme biosynthetic pathway.Porphyrias are induced by various precipitants.Clinical features include abdominal pain, neurologic manifestations, autonomic neuropathy, and mental disturbance.Diagnosis may be delayed because of variable symptoms that mimic other

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Mitochondrial lineage M1 traces an early human backflow to Africa

Abstract Background The out of Africa hypothesis has gained generalized consensus.However, many specific questions remain unsettled.To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in Africa before the exit is puzzling.It has been proposed that the east African clade M1 supports a single origin of haplogr

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Ethical solicitude in medical genetics as perceived from a genetic counselor's perspective in the tribal-based community of Saudi Arabia

Background: The genetics domain is witnessing great advances in diagnosing and predicting genetic diseases.In a clinical setting, autosomal recessive genetic disorders are frequently observed as a result of the high rate of consanguinity.The advances in genomic technologies and methods in recent years Door Stopper have facilitated new tools for gen

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